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NSF49--National Sanitation Foundation Standard Number 49 class II (Laminar Flow) Biohazard Cabinetry to give its full and correct title is the American (USA) standard for class II biohazard cabinets.

NSF49 recognizes various design types of class II microbiological safety cabinets (msc (microbiological safety cabinets) in Europe - BSC (biological safety cabinets) in the USA) only one of which compares to European design criteria. These being Type A1 (similar to an en12469: 2000 recirculating class II msc), Type B1 (30% recirculation and 70% exhaust together with the option of an under worksurface hepa filter), Type B2 (often referred to as total exhaust as there is no recirculating air in the cabinet) and  Type A2 (similar to an en12469: 2000 class II when vented to atmosphere - normally via a thimble exhaust arrangement).

(The above revisions were made in 2002)

NSF49 differs substantially  to en12469 (the European norm).

Remember regardless to which standard a microbiological (biohazard) safety cabinets is manufactured in accordance with, there is no substitute for applying good aseptic techniques, the best cabinet in the world will not compensate for bad user technique! and in our view a full risk assessment should be carried out prior to any cabinet being purchased.